• Agile Sciences Announces Patent for Biofilm Dispersing Compounds

    Agile Sciences, a Centennial Campus company focused on commercializing technologies to inhibit and disperse biofilms, has received notice that its first licensed patent has been approved by the U.S. Patent and Trademark Office.   U.S. Patent No. 7,987,631, entitled "Inhibition and Dispersion of Bacterial Biofilms with Imidazole-Triazole Derivatives," was issued on March 1, 2011.  The patent covers the composition and use of compounds exclusively licensed by Agile Sciences from NC State University. 

    “It is very exciting to report the issuance of this first patent, which serves as the cornerstone to our expanding intellectual property portfolio,” said Agile co-founder and NC State Associate Professor of Chemistry, Dr. Christian Melander.

    Agile Sciences’ proprietary molecules grew out of research by two NC State professors -- Melander and Dr. John Cavanagh, William Neal Reynolds Distinguished Professor of Molecular and Structural Biochemistry.  The pair discovered that their molecules, derived from the Agelas conifera sea sponge, showed great promise in combating antibiotic-resistant infections. Published studies show the compounds break up harmful bacterial accumulations called biofilms, causing the bacteria to revert to a single-celled state that can be destroyed by antibiotics. 

    The Agile Sciences compounds are particularly effective against bacterial infections that are resistant to common antibiotics, including MRSA (methicillin-resistant Staphylococcus aureus). 

    “We anticipate that additional patents covering our proprietary compounds’ composition of matter and fields of use will be issued soon and further strengthen our commercial development efforts,” noted Agile Sciences Director of Operations, Dr. Eva Garland.”

    About Agile Sciences

    Agile Sciences is headquartered on North Carolina State University's Centennial Campus. The company was founded in 2007 by Professors Christian Melander and John Cavanagh of North Carolina State University (NCSU) to provide commercial solutions to those industries plagued by the effects of biofilms. The company's proprietary compounds are derived from the Agelas conifera sea sponge and have been shown to be effective in dispersing biofilms. For additional information, please visit:


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